Analysing leukocyte migration in chemokine receptor null mice

In inflammatory diseases, white blood cells mistakenly attack normal healthy tissues leading to tissue destruction and pain and often death. These white blood cells are attracted to the inflamed tissues by molecules called chemokines. We have been studying chemokines for many years and are expert in this area. This project will use completely novel approaches to examine the mechanisms by which chemokines function and will identify novel therapeutic opportunities for treating inflammatory diseases.