How do chemotherapeutic drugs damage human ovary?

Multiple laboratories, including our own, have used animal models to demonstrate that several drugs
used in the treatment of cancer have harmful effects on the female reproductive system. Different
classes of drugs damage the egg and its associated cells in varying ways. This research project aims
to verify our previous findings in humans, by using donor tissue to determine the nature of the
damage on human ovaries. Increasing numbers of surviving patients over recent years makes this
an increasingly important issue to address. Cisplatin and doxorubicin, two of the most commonly
used drugs in cancer treatment, will be investigated.