Evaluation of recombinant molecules for modulation of the myeloid compartment

The myeloid compartment (a proportion of white blood cells) is actively involved in both the inflammatory and bone erosive aspects of many diseases including rheumatoid arthritis, osteoporosis and multiple myeloma. We have found that the modulation of these cells can inhibit both their inflammatory and erosive nature and thus help to alleviate disease. Research findings from our laboratory have allowed us to design new molecules that can be used to target these cells. The proposed study will evaluate the therapeutic potential of these new molecules.