Examining the functional importance of CCR10 upregulation on neutrophils by TLR ligands

White blood cells remove bacteria and viruses from our bodies by moving to the point of infection and killing the
infectious agent. White blood cell movement is controlled by ‘chemokines’ made at infected sites and white blood
cells possess ‘receptors’ allowing them to detect and move towards the chemokines at the sites of infection.
Interestingly, when white blood cells detect the infectious agents, they change the receptors they express. This
allows them to move to other body sites. We do not fully understand this process and this project will examine
the importance of these changes for fighting infections.