Examining pericentral hepatocytes and their role in homeostatic liver regeneration

The liver is an exemplar of organ regeneration; it has the ability to repair and regrow when injured. Key regenerative cell populations in the liver have been recognised by recent research however, the underlying processes controlling them are yet to fully be identified. In addition, conflict exists with regard to which of these differing cell populations repopulate especially in health. This project aims to look at a specific sub-population of cells during healthy liver regeneration. Both sudden and long term liver disease affects many individuals, and understanding these underlying processes could pave the way for developing new regenerative therapies.