Investigating the pharmacology and cellular expression of GPR92, a novel lipid-sensing receptor

GPR92 is a cell protein found in the membrane of cells that communicate pain to the brain, so that we are aware that we feel pain. It is also found in cells involved in inflammation. It is thought that GPR92 is involved in the process of registering the pain associated with inflammatory conditions such as multiple sclerosis and infectious injury inflammation. This project will investigate how the protein sends signals within the cell, improving understanding of the communication between the inflammation site and the pain felt. The results may point to future drug development to block the process.