The janus face of FXII – a potential role in coagulation and fibrinolysis

Recent work has shown that the protein factor XII is involved in blood clot formation within vessels, but not in stopping bleeding after injury. Our work identified polyphosphate, a component of platelets, as the first ‘natural’ activator of factor XII. Preliminary work suggests factor XII can act both in the formation and breakdown of clots. This project will investigate the ability of polyphosphate to regulate the function of factor XII in breaking down blood clots. The ultimate goal of our studies is to develop a better understanding on how to treat individuals at risk of strokes or heart attacks.