The Keap1-Nrf2 complex as a cellular sensor of oxidative stress and therapeutic target during normothermic regional perfusion of donor livers

After circulatory death, when the heart stops beating, there is no oxygen being delivered to tissues. Around 40% of livers that are transplanted in the UK are donated after circulatory death, and these livers have been shown to have poorer outcomes. During the period after circulatory death and before the liver is cooled, the liver can be damaged. This study will consider the role of two proteins, Nrf2 and Keap1, with the aim of finding a way to reduce or even eliminate this injury. The benefit is that more liver transplants would be possible with better short and long-term function.