Methods to correct chimares due to whole genome amplification in third generation sequencing

After the publication of the human genome in 2001, the technologies to build genomes improved. The cost dropped by a factor of over 10,000. If the genome could be seen as a puzzle, rather than having trillions of very small pieces, now we have millions of larger puzzle pieces. But when producing these pieces, errors occur, namely merging two puzzle pieces into one. We are generating a computational approach to find these “chimeric” pieces with and split them onto two. That will help to puzzle the final pictures with less mistakes. We are going to apply this to several genome project.