Potential novel antibiotics from microorganisms of under explored extreme marine habitats

Endophytic microorganisms with potentially novel biosynthetic capabilities to produce new antibiotics have been obtained from underexplored areas which experience environmental stress. Genomic and metabolomic tools will be employed to dereplicate microorganism in order to focus on those with novel chemistry and mechanism of action. The main objective of this summer project is to explore the production of new antimicrobials from actinomycetes and to pilot an efficient cultivation and production processes at a small scale which whilst maintaining or enhancing synthesis of the targeted bioactive compounds.