Studying the amyloid cascade hypothesis in a novel model of Alzheimer’s disease

Alzheimer’s disesae is the most common cause of dementia in the elderly  affecting approximately 55,000 people in Scotland.  Currently we have no effective treatments to slow or reverse the disease process.  In order to develop effective medicines, we need to better understand how the brain degenerates during Alzheimer’s disease.  To that end, our lab has developed a new disease model to test how two of the key pathologies in the disease, called amyloid beta and tau, are related.  The student will help characterise this new model  using advanced microscopic techniques.