Validation of a siRNA cocktail for targeting oncogenes in cancer cell lines

The main reason for treatment failure in cancer is that the cancer cells become resistant to treatments over time. Cancer cells have dysregulated growth and become immortal by high jacking certain cellular drivers. New cancer treatments block such drivers inside the cells, but over time cancer cells will switch to new drivers to keep growing. We are developing new ways of blocking several drivers simultaneously to prevent the cancer from performing this switch. By finding new ways of blocking these drivers in cancer cells we can improve the next generation of cancer drugs and help prevent resistance building up to them.