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Associations between declining antibiotic use in primary care in Scotland and hospitalization with infection and patient satisfaction: longitudinal population study, 2022, J Antimicrob Chemother 24 June. Guthrie I, Malcolm W, Nogueira R, Sneddon J, Seaton RA, Marwick CA. DOI: 10.1093/jac/dkac191 Link to publication
Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid, 2022, European Journal of Pharmaceutics and Biopharmaceutics, Vol 177, 126-134, August. Silva MI, Khadra I, Pyper K, Halbert GW. DOI: 10.1016/j.ejpb.2022.06.005 Link to publication
The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI 1, 2022, Journal of Thrombosis and Haemostasis Vol 17, Issue 7, 1548-1555. Whyte CS, Simpson M*, Morrow GB, Wallace CA, Mentzer AJ, Knight JC, Shapiro S, Curry N, Bagots CN, Watson H, Cooper JG7, Mutch NJ. DOI: 10.1111/jth.14872 Link to publication
Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer, 2022, Br J Cancer, 1 July. Nicholson HA, Sawers L, Clarke RG, Hiom KJ, Ferguson MJ, Smith G. DOI: 10.1038/s41416-022-01899-z Link to publication
Macrophages trigger cardiomyocyte proliferation by increasing epicardial vegfaa expression during larval zebrafish heart regeneration, 2022, Developmental Cell, Jun 9. Bruton FA, Kaveh A, Ross-Stewart KM, Matrone G, Oremek ME, Solomonidis EG, Tucker CS, Mullins JJ, Lucas CD, Brittan M, Taylor JM. DOI: 10.1016/j.devcel.2022.05.014 Link to publication
Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?, 2022, Frontiers in Pharmacology 13. Budgett RF, Bakker G, Sergeev E, Bennett KA, Bradley SJ. DOI: 10.3389/fphar.2022.893422 Link to publication
Right ventricular dysfunction in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated, 2022, Anaesthesia, McCall PJ, Willder JM, Stanley BL, Messow C-M, Allan J, Gemmell L, Puxty A, Strachan D, Berry C, Shelley BG. DOI: 10.1111/anae.15745 Link to publication
Volumetric scalability of microfluidic and semi-batch silk nanoprecipitation methods, 2022, Molecules 27, 2368. Matthew SAL, Rezwan R, Perrie Y, Seib FP. DOI: 10.3390/molecules27072368 Link to publication
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity, 2022, Redox Biol. 2022 Mar 17;51:102291. Casares L, Moreno R, Ali KX, Higgins M, Dayalan Naidu S, Neill G, Cassin L, Kiib AE, Svenningsen EB, Minassi A, Honda T, Poulsen TB, Wiel C, Sayin VI, Dinkova-Kostova AT, Olagnier D, de la Vega L. DOI: 10.1016/j.redox.2022.102291 Link to publication
5-FU precursor designed to evade anabolic and catabolic drug pathways and activated by Pd chemistry in vitro and in vivo, 2022, J Med Chem, 65, 552-561. Adam C, Bray TL, Perez-Lopez AM, Hong Tan E, Rubio-Ruiz B, Baillache DJ, Houston DR, Salji MJ, Leung HY, Unciti-Broceta AA. DOI: 10.1021/acs.jmedchem.1c01733 Link to publication
Impact of silk hydrogel secondary structure on hydrogel formation, silk leaching and in vitro response, 2022, Nature Scientific Reports 12:3729. Egan G, Phuagkhaopong S, Matthew SAL, Connolly P, Seib FP. DOI: 10.1038/s41598-022-07437-4 Link to publication
Mixing and flow-induced nanoprecipitation for morphology control of silk fibroin self-assembly, 2022, RSC Adv 12, 7357-7373. Matthew SAL, Rezwan R, Kaewchuchuen J, Perrie Y, Seib FP. DOI: 10.1039/d1ra07764c Link to publication
Enhanced fluorescence from semiconductor quantum dot-labelled cells excited at 280 nm, 2022, Methods Appl Fluoresc 10, 025004. McFarlane M, Hall N, McConnell G. DOI: 10.1088/2050-6120/ac5878 Link to publication
Small molecule kinase inhibitor drugs (1995-2021): Medical indication, pharmacology, and synthesis, 2022, J Med Chem 65: 1047-1131. Ayala-Aguilera, C. C.; Valero, T.; Lorente-Macias A; Baillache DJ; Croke S; Unciti-Broceta A. D10.1021/acs.jmedchem.1c00963OI: Link to publication
Immediate effect of a spinal mobilisation intervention on muscle stiffness, tone and elasticity in subjects with lower back pain - A randomized cross-over trial, 2022, Journal of Bodywork and Movement Therapies, 29, 60-67. Hamilton RI, Garden CLP, Brown S.J. DOI: 10.1016/j.jbmt.2021.09.032 Link to publication
How a part-time fellowship enticed a scientist back to academia, 2022, Nature, January. James R. DOI: 10.1038/d41586-022-00042-5 Link to publication
Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish, 2022, Development 149(8). Kaveh A, Bruton FA, Oremek MEM, Tucker CS, Taylor JM, Mullins JJ, Rossi AG, Denvir MA. DOI: 10.1242/dev.199636 Link to publication
High throughput hemogram of T-cell subsets using digital holographic microscopy and deep learning, 2021, BioRX. Gupta RK, Malcolm GPA, Hempler N, Dholakia K, Powis SJ. DOI: 10.1101/2021.12.23.473983 Link to publication
Modelling epilepsy in the mouse: challenges and solutions, 2021, Dis Model Mech Feb 22;14(3):dmm047449. Marshall GF, Gonzalez-Sulser A, Abbott CM. DOI: 10.1242/dmm.047449 Link to publication
Information seeking behaviours and uncertainty around accessing primary care in the changing landscape of the COVID-19 pandemic: a qualitative study, 2021, BJGP Open 1 December. Brown LR, Williams AJ, Shaw K, Ozakinci G, van Beusekom MM. DOI: 10.3399/BJGPO.2021.0151 Link to publication
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, are potent BACH1 inhibitors, 2021, bioRxiv 2021.10.29.466411. Casares L, Moreno R, Higgins M, Dayalan Naidu S, Neill G, Cassin L, Kiib AE, Svenningsen EB, Honda T, Poulsen TB, Dinkova-Kostova AT, Olagnier D, de la Vega L. DOI: 10.1101/2021.10.29.466411 Link to publication
Identification and Characterization of an Affimer Affinity Re-agent for the Detection of the cAMP Sensor, EPAC1, 2021, Cells 10 (9):2307. Buist HK, Luchowska-Sta-ska U, van Basten B et al. DOI: 10.3390/cells10092307 Link to publication
A prenylated dsRNA sensor protects against severe COVID-19, 2021, Science Sep 28. Wickenhagen A, Sugrue E, Lytras S et al. DOI: 10.1126/science.abj3624 Link to publication
Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish, 2021, Development Sep 15, 199636. Kaveh A, Bruton FA, Oremek MEM, Tucker CS, Taylor JM, Mullins JJ, Rossi AG, Denvir MA. DOI: 10.1242/dev.199636 Link to publication
Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease, 2021, bioRxiv 2021.04.29.440753. Scarpa M, Molloy C, Jenkins L et al. DOI: 1 0.1101/2021.04.29.440753 Link to publication
Predicting 10-year stroke mortality: development and validation of a nomogram, 2021, Acta Neurol Belg. Szlachetka WA, Pana TA, Mamas MA, Bettencourt-Silva JH, Metcalf AK, Potter JF, McLernon DJ, Myint PK DOI: 10.1007/s13760-021-01752-9 Link to publication
Models of osteoarthritis: Relevance and new insights, 2021, Calcif Tissue Int 109:243–256. Samvelyan HJ, Hughes D, Stevens C, Staines KA. DOI: 10.1007/s00223-020-00670-x Link to publication
Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity, 2021, ChemRxiv. Cambridge: Cambridge Open Engage; This content is a preprint and has not been peer-reviewed. Klein V, Bond AG, Craigon C, Lokey SR, Ciulli A. DOI: 10.33774/chemrxiv-2021-47tqn Link to publication
Pharmaceuticals in wastewater treatment plants: A systematic review on the substances of greatest concern responsible for the development of antimicrobial resistance, 2021, Appliced Sciences 11, 6670. . Frascaroli G, Reid D, Hunter C, Roberts J, Helwig K, Spencer J, Escudero A. DOI: 10.3390/app11156670 Link to publication
On synthetic instrument response functions of time-correlated single-photon counting based fluorescence lifetime imaging analysis, 2021, Frontiers in Physics, 9, [635645]. Xiao D, Sapermsap N, Safar M, Cunningham MR, Chen Y, and Li D D-U. DOI: 10.3389/fphy.2021.635645 Link to publication
Dynamic fluorescence lifetime sensing with CMOS single-photon avalanche diode arrays and deep learning processors, 2021, Biomed Optics Express, 12(6), 3450-3462. Xiao D, Zang Z, Sapermsap N, Wang, Q Xie, W, Chen Y and Li DD-U. DOI: 10.1364/BOE.425663 Link to publication
Non‐pharmacological interventions for preventing delirium in hospitalised non‐ICU patients, 2021, Epigenetics and Chromatin 14:31. Fitzgerald E, Sinton MC, Wernig-Zorc S, Morton NM, Holmes MC, Boardman JP, Drake AJ. DOI: 10.1002/14651858.CD013307.pub2 Link to publication
Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress, 2021, Epigenetics and Chromatin 14:31. Fitzgerald E, Sinton MC, Wernig-Zorc S, Morton NM, Holmes MC, Boardman JP, Drake AJ. DOI: 10.1186/s13072-021-00405-8 Link to publication
Correction: Versatile hybrid acoustic micromixer with demonstration of circulating cell-free DNA extraction from sub-ml plasma samples, 2021, Lab on a Chip, Correction of 20, 741-748. Conde A, Keraite I, Ongaro AE, Kersaudy-Kerhoas M. DOI: 10.1039/D1LC90069B Link to publication
FMALE score: Combining practical risk scales to improve preoperative predictive accuracy in emergency general surgery: A multi-centre prospective cohort study, 2021, Am J Surgery, 26 April. Wong PY, Ablett AD, Myint PK, Carter B, McCarthy K, Stechman M, Pearce L, Hewitt J. DOI: 10.1016/j.amjsurg.2021.04.009 Link to publication
On synthetic instrument response functions of time-correlated single-photon counting based fluorescence lifetime imaging analysis, 2021, Frontier in Physics, 02 March. Xiao D, Sapermsap N, Safar M, Cunningham M, Chen Y, Li D. DOI: 10.3389/fphy.2021.635645 Link to publication
Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2, 2021, Sci Reports 11(1):9092. Fitzgerald E, Roberts J, Tennant DA, Boardman JP, Drake AJ. DOI: 10.1038/s41598-021-88757-9 Link to publication
Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo, 2021, Nat Commun 12, 2369. Benson S, de Moliner F, Fernandez A. et al. DOI: 10.1038/s41467-021-22578-2 Link to publication
Automated Detection and Classification of Desmoplastic Reaction at the Colorectal Tumour Front Using Deep Learning, 2021, Cancers, 13, 1615. Nearchou IP, Ueno H, Kajiwara Y, Lillard K, Mochizuki S, Takeuchi K, Harrison DJ, Caie PD. DOI: 10.3390/cancers13071615 Link to publication
Electromyographic assessment of the lower leg muscles during concentric and eccentric phases of standing heel raise, 2021, Brain, Behaviour and Immunity - Health Volume 13, May, 100219. Fitzgerald E, Boardman JP, Drake AJ. DOI: 10.3390/healthcare9040465 Link to publication
Early life stress and LPS interact to modify the mouse cortical transcriptome in the neonatal period, 2021, Brain Behav Immun Health. Feb 13;13:100219. Fitzgerald E, Boardman JP, Drake AJ. DOI: 10.1016/j.bbih.2021.100219 Link to publication
Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases, 2021, Open Forum Infect Dis. Feb; 8(2): ofaa640. Dolby HW, Potey P, Wilder-Smith AB, Clohisey S, Millar JE, Baillie JK, Dorward DA, Lucas CD, Russell CD. DOI: 10.1093/ofid/ofaa640 Link to publication
Image‐based computational fluid dynamics for estimating pressure drop and fractional flow reserve across iliac artery stenosis: A comparison with in‐vivo measurements, 2021, Int J Numer Method Biomed Eng. Jan 15; e34. Skopalik S, Barrientos PH, Matthews J, Radjenovic A, Mark P, Roditi G, Paul MC.27. DOI: 10.1002/cnm.3437 Link to publication
A comparison of methods for studying the tumor microenvironment’s spatial heterogeneity in digital pathology specimens, 2021, J Pathol Inform 12:6. Nearchou IP, Soutar A, Ueno H, Harrison DJ, Arandjelovic O, Caie PD. DOI: 10.4103/jpi.jpi_26_0 Link to publication
Tissue-Specific Immunopathology in Fatal COVID-19, 2021, Am J Respir Crit Care Med Jan 15;203(2):192-201. Dorward DA, Russell CD, Um IH et al. DOI: 10.1164/rccm.202008-3265OC Link to publication
Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for Covid-19, 2021, Frontiers in Immunology Jan. Cooper R, Fraser AR, Smith L, Burgoyne P, Imlach SN, Jarvis LM, Turner DM, Zahra S, Turner ML, Campbell JDM. DOI: 10.3389/fimmu.2020.598402 Link to publication
One-dimensional deep learning architecture for fast fluorescence lifetime imaging, 2021, IEEE Journal of Selected Topics in Quantum Electronics 27 (4). Xiao D, Chen Y, Li D. DOI: 10.1109/JSTQE.2021.3049349 Link to publication
Designing stapled peptides to inhibit protein-protein interactions: An analysis of successes in a rapidly changing field, 2021, Peptide Science 113:e24191. Bluntzer MTJ, O'Connell J, Baker TS, Michel J, Hulme AN. DOI: 10.1002/pep2.24191 Link to publication
Lessons from research advances in spinal cord repair, 2020, British Pharmaacology Society Blog, 19 May. Viskontas M. Link to publication
Deep learning enabled laser speckle wavemeter with a high dynamic range., 2020, Laser & Photonics Reviews 14, 9, 2000120. Gupta R, Bruce GD, Powis SJ, Dholakia K. DOI: 10.1002/lpor.202000120 Link to publication
CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake, 2020, Mol Psychiatry. DOI: 10.1038/s41380-020-0707-7 Link to publication
Extended Kalman filtering projection method to reduce the 3σ noise value of optical biosensors, 2020, ACS Sensors 5, 11, 3474–3482. Li K, Gupta R, Drayton A, Barth I, Conteduca D, Reardon C, Dholakia K and Krauss TF. DOI: 10.1021/acssensors.0c01484 Link to publication
A novel simplified biomechanical assessment of the heel pad during foot plantarflexion, 2020, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 235(2), 197-207 Ugbolue UC, Yates EL, Rowland KE, Wearing SC, Gu Y, Lam W-K, Baker JS, Sculthorpe NF & Dutheil F. DOI: 10.1177/0954411920971069 Link to publication
Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite–Collagen Bone Cements, 2020, CS Applied Bio Materials 3 (8), 5056-5066. Sarrigiannidis SO, Moussa H, Dobre O, Dalby MJ, Tamimi F, Salmeron-Sanchez M. DOI: 10.1021/acsabm.0c00555 Link to publication
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 inrenal tubular cells, 2020, EBioMedicine 62, 103092. Matthews O, Morrison EE, Tranter JD, Starkey Lewis P et al. DOI: 10.1016/j.ebiom.2020.103092 Link to publication
Dimeric structure of IRAK3 pseudokinase suggests an allosteric mechanism of negative regulation, 2020, Structure 29, 1-19. Lange SM, Nelen MI, Cohen P, Kulathu Y. DOI: 10.1016/j.str.2020.11.004 Link to publication
Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences, 2020, Early Human Development 150, 105190. Fitzgerald E, Hor K, Amanda J. Drake A. DOI: 10.1016/j.earlhumdev.2020.105190 Link to publication
Cx31.1 expression is modulated in HaCaT cells exposed to UV-induced damage and scrape-wounding, 2020, Journal of Cellular Physiology Vol 236 (2), 911-920. Nugent L, Ofori-Frimpong B, Martin PE, Green CR, Wright CS. DOI: 10.1002/jcp.29901 Link to publication
Extracellular Vesicle the Promotion of Cardiac Neovascularisation, 2020, Frontiers in Physiol. Sep, Vol 11. Kesidou D, da Costa Martins PA, de Windt LJ, Brittan M, Beqqali A and Baker AH. DOI: 10.3389/fphys.2020.579892 Link to publication
Silk Nanoparticle Manufacture in Semi-Batch Format, 2020, ACS Biomater Sci Eng, 3 Nov. Matthew SAL, Totten JD, Phuagkhaopong S, Egan G, Witte K, Perrie Y, Seib FP. DOI: 10.1021/acsbiomaterials.0c01028.s001 Link to publication
Engineered membranes for residual cell trapping on microfluidic blood plasma separation systems. A comparison between porous and nanofibrous (electrospun) membranes, 2020, BioRxiv:, May. Lopresti F, Keraite I, Ongaro A, Howarth N, La Carrubba V and Kersaudy-Kerhoas M. DOI: 10.1101/2020.05.21.107813 Link to publication
PIK3CA mutation enrichment and quantitation from blood and tissue, 2020, Scientific Reports, 10, 17082. Keraite, I Alvarez-Garcia V, Garcia-Murillas I, Beaney M, Turner NC, Bartos C, Oikonomidou O, Kersaudy-Kerhoas M, Leslie NR. DOI: 10.1038/s41598-020-74086-w. Link to publication
Versatile hybrid acoustic micromixer with demonstration of circulating cell-free DNA extraction from sub-ml plasma samples, 2020, Lab on a Chip, 20, 741-748. Conde A, Keraite I, Ongaro AE, Kersaudy-Kerhoas M. DOI: 10.1039/c9lc01130g Link to publication
Live Imaging of Heart Injury in Larval Zebrafish Reveals a Multi-Stage Model of Neutrophil and Macrophage Migration, 2020, Frontiers in Cell and Developmental Biology, 8 (579943). Kaveh A, Bruton F, Buckley C, Oremek M, Tucker C, Mullins J, Taylor J, Rossi A. and Denvir M. DOI: 10.3389/fcell.2020.579943 Link to publication
Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis, 2020, Acta Neuropathologica Communications, 8 (135). Hayden L, Semenoff T, Schultz V, Merz SF, Chapple KJ, Rodriguez M, Warrington AE, Shi X, McKimmie CS, Edgar JM, Thümmler K, Linington C, and Pingen M. DOI: 10.1186/s40478-020-01011-7 Link to publication
4D flow MRI for non-invasivemeasurement of blood flow inthe brain: A systematic review, 2020, Journal for Cerebral Blood Flow and Metabolism, 0 (0), 1-13. Morgan A, Thrppleton MJ, Wardlaw JM, Marshall I. DOI: 10.1177/0271678X20952014 Link to publication
The burden of psychotropic and anticholinergic medicines use in care homes: population-based analysis in 147 care homes, 2020, Age and Ageing, 1-7. Grill P, Marwick C, De Souza N, Burton JK, Hughes C, Guthrie B. DOI: 10.1093/ageing/afaa122 Link to publication
Sex differences in heel pad stiffness during in-vivo loading and unloading, 2020, Journal of Anatomy, 237(3), 520-528. Ugbolue UC, Yates EL, Wearing SC, Gu Y, Lam W-K, Valentin S, Baker JS, Dutheil F, Sculthorpe NF. DOI: DOI: 10.1111/joa.13207 Link to publication
Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold, 2020, RSC Medicinal Chemistry, 8 September. Baillache DJ, Unciti-Broceta, A. DOI: 10.1039/D0MD00227E Link to publication
Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays, 2020, Virchows Arch 477, 409–420. Shiraishi, T., Shinto, E., Nearchou, I.P., Tsuda H., Kajiwara Y., Einama T., Caie P.D., Kishi Y. and Ueno H. DOI: 10.1007/s00428-020-02775-y Link to publication
Stereoselective Synthesis of Allele-Specific BET Inhibitors, 2020, Org Biomol Chem 18, 7535. Bond A, Testa A, Ciulli A. DOI: 10.1039/d0ob01165g Link to publication
Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients, 2020, npj Digit. Med. 3, 71. Nearchou IP, Gwyther BM, Georgiakakis ECT, Gavriel CG, Lillard K, Kajiwara Y, Ueno H, Harrison DJ, Caie PD. DOI: 10.1038/s41746-020-0275-x Link to publication
Efficiently simulating an endograft deployment: A methodology for detailed CFD analyses, 2020, Annals of Biomedical Engineering. Kyriakou F, Maclean C. DOI: 10.1115/IPACK2019-6395 Link to publication
Analysing the cross-section of the abdominal aortic aneurysm neck and its effects on stent deployment, 2020, Nature Scientific Reports, 10, Article Number 4673. Kyriakou F, Dempster W and Nash D. DOI: 10.1038/s41598-019-53820-z Link to publication
Characterisation of a deep-ultraviolet light-emitting diode emission pattern via fluorescence, 2020, Measurement Science and Technology 31(7): 077001. McFarlane M and McConnell G. DOI: 10.1088/1361-6501/ab78c1 Link to publication
Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis, 2020, Cardiovascular Research Mar 1;116(3):721-735. Rios FJ, Zou ZG, Harvey AP, Harvey KY, Nosalski R, Anyfanti P, Camargo LL, Lacchini S, Ryazanov AG, Ryazanova L, McGrath S, Guzik TJ, Goodyear CS, Montezano AC, Touyz RM. DOI: 10.1093/cvr/cvz164 Link to publication
Exclusion rates in randomized controlled trials of treatments for physical conditions: a systematic review, 2020, Trials 21, 228. He J, Morales DR & Guthrie B. DOI: 10.1038/s41582-020-0311-0 Link to publication
Multi- target approaches to CNS repair: Olfactory mucosalderived mesenchymal stromal cells and heparan sulphate proteoglycans, 2020, Nature Rev Neural, 25 Feb. Lindsay SL. McCanney GA, Willison AG, Barnett SC. DOI: 10.1038/s41582-020-0311-0 Link to publication
Pyrazolopyrimidine Library Screening in Glioma Cells Discovers Highly Potent Antiproliferative Leads That Target the PI3K/mTOR Pathway, 2020, Bioorganic and Medicinal Chemistry, 28 (1), 115214. Valero T, Baillache DJ, Fraser C, Myers SH, Unciti-Broceta, A. DOI: 10.1016/j.bmc.2019.115215 Link to publication
Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication, 2019, Cells 8(2), 120. Saiz-Ros N, Czapiewski R, Epifano I, et al. DOI: 10.3390/cells8020120 Link to publication
TGFβ signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia, 2019, BioRxiv. Low EL, Schwartze JT, Kelly DJ, Shaw AS, Thorikay M, McClure J, McBride M, Arias-Rivas S, Francis SE, Morrell NW, Delles C, Havenga MJ, Nicklin SA, Ten Dijke P, Baker AH, Bradshaw AC. DOI: 10.1101/860320v1 Link to publication
A methodology to quantify the geometrical complexity of the abdominal aortic aneurysm, 2019, Kyriakou F, Dempster W andNash D. Nature Scientific Reports, 9, Article Number 17379. DOI: 10.1038/s41598-019-53820-z Link to publication
Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML, 2019, Biochem Soc Trans 47 (5): 1307–1325. Busch C and Wheadon H. DOI: 10.1042/BST2019022 Link to publication
The Use of Myelinating Cultures as a Screen of Glycomolecules for CNS Repair, 2019, Biology (Basel) 8(3). McCanney GA, Lindsay SL, McGrath MA, Willison HJ, Moss C, Bavington C, Barnett SC. DOI: 10.3390/biology8030052 Link to publication
MyelinJ: an ImageJ macro for high throughput analysis of myelinating cultures., 2019, Bioinformatics. 35(21):4528-4530. Whitehead MJ, McCanney GA, Willison HJ, Barnett SC. DOI: 10.1093/bioinformatics/btz403 Link to publication
Deep learning enabled laser speckle wavemeter with a high dynamic range, 2019, arXiv:1910.10702 [physics.optics]. Gupta R, Bruce G, Powis S, Dholakia K. Link to publication
Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction, 2019, Frontiers in Physiology, 10, 1365. O'Sullivan J et al. DOI: 10.3389/fphys.2019.01365 Link to publication
TGF-β in Vascular Pathobiology, 2019, Schwartze J. Chapter in the “Textbook of Vascular Medicine". Springer Nature Switzerland AG. Touyz R, Delle C (Eds) DOI: 10.1007/978-3-030-16481-2_13 Link to publication
Adaptive prospective optical gating enables day-long 3D time-lapse imaging of the beating embryonic zebrafish heart, 2019, Nature Communications 10(1):5173. Taylor JM, Nelson CJ, Bruton FA, Kaveh A, Buckley C, Tucker CS, Rossi AG, Mullins JJ, Denvir MA. DOI: 10.1038/s41467-019-13112-6 Link to publication
Evaluation of a new approach for modelling full ring stent bundles with the inclusion of manufacturing strains, 2019, Annals of Biomedical Engineering p13. Kyriakou F, Bow D, Dempster W, Brodie R & Nash D. DOI: 10.1007/s10439-019-02322-0 Link to publication
Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid-1 receptor gene promoter; implications for cannabinoid pharmacogenetics, 2019, Hum Mutat Oct 14. Hay EA, Cowie P, McEwan AR, Ross R, Pertwee RG, MacKenzie A. DOI: 10.1002/humu.23931 Link to publication
Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour, 2019, Psychoneuroendocrinology 109:104407. Hay EA, McEwan A, Wilson D, Barrett P, D'Agostino G, Pertwee RG, MacKenzie A. DOI: 10.1016/j.psyneuen.2019.104407 Link to publication
Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease-associated psychological morbidity, 2019, Br J Dermatol. Apr 13. Bain KA, McDonald E, Moffat F, Tutino, M, Castelino M, Barton A, Cavanagh J, Ijaz UZ, Siebert S, McInnes IB, Astrand A, Holmes S, Milling SWF. DOI: 10.1111/bjd.18008 Link to publication
SCOTfluors: small, conjugatable, orthogonal and tunable fluorophores for in vivo imaging of cell metabolism, 2019, Angew Chem Int Ed 58, 6911-6915. Benson S, Frnandez A, Barth N et al. DOI: 10.1002/anie.201900465 Link to publication
Novel Internationally Verified Method Reports Desmoplastic Reaction as the Most Significant Prognostic Feature For Disease-specific Survival in Stage II Colorectal Cancer, 2019, American Journal of Surgical Pathology, 43(9):1239-1248. Nearchou IP, Kajiwara Y, Mochizuki S, Harrison D, Caie P, Ueno H. DOI: 10.1097/PAS.0000000000001304 Link to publication
Individual and Combined Impact of Heart Failure and Atrial Fibrillation on Ischemic Stroke Outcomes A Prospective Hospital Register Cohort Study, 2019, Stroke Vol 50, No 7. Pama TA, McLernon DJ, Mamas MA, Bettencourt-Silva JH, Metcalf AK, Potter JF, Myint PK. DOI: 10.1161/STROKEAHA.119.025481 Link to publication
Low sulfated heparins target multiple proteins for central nervous system repair, 2019, Glia, 67, 4, pp668-687. McCanney GA, McGrath MA, Otto TD, Burchmore R, Yates EA, Bavington CD, Willison HJ, Turnbull JE, Barnett SC. DOI: doi.org/10.1002/glia.23562 Link to publication
Cortical thickness, white matter hyperintensities, and cognition after stroke, 2019, International Journal of Stroke, April. Dickie DA, Gardner K, Wagener A, Wyss A, Arba F, Wardlaw JM, Dawson J. DOI: doi.org/10.1177/1747493019851291 Link to publication
Genetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene promoter implications for cannabinoid pharmacogenetics, 2019, BioRxiv. Hay E, Cowie P, McEwan A, Wilson D, Ross R, Barrett P, Pertwee RG, MacKenzie A. DOI: doi.org/10.1101/544585 Link to publication
CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests its role in anxiety and male alcohol intake, 2019, BioRxiv. McEwan A, Hay E, Davidson C, Turnbull Y, Marini P, Wilson D, McIntosh A, Adams MJ, Murgatroyd C, Barrett P, Delibegovic M, Clark, T, MacKenzie A. DOI: doi.org/10.1101/572065 Link to publication
The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis, 2019, Cellular Signalling, Aug, 60, pp39-56. Gómez-Herranz M, Nekulova M, Faktor J, Hernychova L, Kote S, Sinclair EH, Nenutil R, Vojtesek B, Ball KL, Hupp TR. DOI: 10.1016/j.cellsig.2019.03.024 Link to publication
Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031, 2019, Scientific Reports, 9, 7643. Sarr A, Bre J, Um I, Chan T, Mullen P, Harrison DJ, Reynolds PA. DOI: 10.1038/s41598-019-44089-3 Link to publication
Automated Analysis of Lymphocytic Infiltration, Tumor Budding, and Their Spatial Relationship Improves Prognostic Accuracy in Colorectal Cancer, 2019, Cancer Immunology Research, 7(4), pp.609-620. Nearchou IP, Lillard K, Gavriel CG, Ueno H, Harrison DJ, Caie PD. DOI: 10.1158/2326-6066.CIR-18-0377 Link to publication
Label-free optical hemogram of granulocytes enhanced by artificial neural networks, 2019, Optics Express 27, 13706-13720. Gupta R, Chen M, Malcolm GPA, Hempler N, Dholakia K, Powis S. DOI: doi.org/10.1364/OE.27.013706 Link to publication
An in vitro model for studying CNS white matter, 2019, F1000 Research. Bijland S, Thomson G, Euston M, Michail K, Thümmler K, Mücklisch S, Crawford CL, Barnett S, McLaughlin M, Anderson J, Linington C, Brown E, Kalkman ER, Edgar J. DOI: f1000research.com/articles/8-117/v1 Link to publication
Neural cell cultures to study spinal cord injury, 2018, Drug Discovery Today: Disease Models:25-26C;11-20. McCanney GA, Whitehead M, McGrath MA, Lindsay SL, Barnett SC. Link to publication
Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4, 2018, Nutritional Neuroscience. July. Sergi D, Morris AC, Kahn DE., McLean, FH, Hay EA, Kubitz P, MacKenzie A, Martinoli MG, Drew JE, Williams LM. DOI: 10.1080/1028415X.2018.1501533 Link to publication
Protease-activated receptor-2 in synovial joint pathobiology, 2018, Frontiers in Endocrinology, 9, p.257. McCulloch K, McGrath S, Huesa C, Dunning L, Litherland G, Crilly A, Hultin L, Ferrell WR Lockhart JC, Goodyear CS. DOI: 10.3389/fendo.2018.0025 Link to publication
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal, 2018, Cell Death & Disease. Volume 9, Article number: 927. Toofan P, Busch C, Morrison H, O'Brien S, Jørgensen H, Copland M, Wheadon H. DOI: 10.1038/s41419-018-0905-2 Link to publication
Laser ablation of polylactic acid sheets for the rapid prototyping of sustainable, single-use, disposable medical micro-components, 2018, ACS Sustainable Chemistry & Engineering 6: 4: 4899–4908. Alfredo Edoardo Ongaro, Keraite I, Liga A, Conoscenti G, Coles S, Schulze H, Bachmann TT, Parvez K, Casiraghi C, Howarth NM, La Carrubba V, Kersaudy-Kerhoas M. DOI: 10.1021/acssuschemeng.7b04348 Link to publication
A simple and robust real-time qPCR method for the detection of PIK3CA mutations, 2018, Scientific Reports 8: 4290. Alvarez-Garcia V, Bartos C, Keraite I, Trivedi U, Brennan PM, Kersaudy-Kerhoas M, Gharbi K, Oikonomidou O, Leslie NR. DOI: 10.1038/s41598-018-22473-9 Link to publication
Cognitive impairment is associated with mortality in older adults in the emergency surgical setting: Findings from the Older Persons Surgical Outcomes Collaboration (OPSOC): A prospective cohort study, 2018, Surgery, 165, 5, p978–984 . Ablett A, McCarthy K, Carter B, Pearce L, Stechman M, Moug M, Hewitt J, Myint PK, Older Persons Surgical Outcomes Collaboration DOI: 10.1016/j.surg.2018.10.013 Link to publication
Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient, 2018, Nature Scientific Reports 8: 14672. Mulholland T, McAllister M. DOI: 10.1038/s41598-018-33055-0 Link to publication
Full UPF3B function is critical for neuronal differentiation of neural stem cells, 2018, Molecular Brain 8: 33. Alrahbeni T, Sartor F, Anderson J, Miedzybrodzka M, McCaig C, Müller B. DOI: 10.1186/s13041-015-0122-1 Link to publication
Mutation of genes controlling mRNA metabolism and protein synthesis predisposes to neurodevelopmental disorders, 2018, Biochemical Society Transactions 43: 1259-1265. Sartor F, Anderson J, McCaig C, Miedzybrodzka Z, Müller B. DOI: 10.1038/s41598-018-33055-0 Link to publication
Preterm birth and the risk of neurodevelopmental disorders - Is there a role for epigenetic dysregulation?, 2018, Current Genomics 19: 7. Fitzgerald E, Boardman JP, Drake A. DOI: 10.2174/1389202919666171229144807 Link to publication
The potential of a novel class of EPAC-selective agonists to combat cardiovascular inflammation, 2017, Journal of Cardiovascular Development and Disease 4: 4: 22. Barker G, Parnell E, Buist H, Adams DR, Yarwood S. DOI: 10.3390/jcdd4040022 Link to publication
Effect of antiplatelet therapy (Aspirin + Dipyridamole versus Clopidogrel) on mortality outcome in ischemic stroke, 2018, American Journal of Cardiology 122: 6: 1085–1090. Barlas RS, Loke YK, Mamas MA, Bettencourt-Silva JH, Ford I, Clark AB, Bowles KM, Metcalf AK, Potter JF, Myint PK. DOI: 10.1016/j.amjcard.2018.05.043 Link to publication
Long-term facotors associated with fall ad fractures poststroke, 2018, Frontiers in Neurology 9: 210. Foster EJ, Barlas RS, Bettencourt-Silva JH, Clark AB, Metcalf AK, Bowles KM, Potter JF, Myint PK. DOI: 10.3389/fneur.2018.00210 Link to publication
The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis, 2017, Journal of Allergy and Clinical Immunology 139: 1946–1956. Kurowska-Stolarska M, Hasoo MK, Welsh DJ, Stewart L, McIntyre D, Morton BE, Johnstone S, Miller AM, Asquith DL, Millar NL, Millar AB, Feghali-Bostwick CA, Hirani N, Crick PJ, Wang Y, Griffiths WJ, McInnes IB, McSharry C. DOI: 10.1016/j.jaci.2016.09.021 Link to publication
A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity, 2017, Nature Scientific Reports 7: 3598. Iyer RS, Chatham L, Sleigh R, Meek DW (2017) DOI: 10.1038/s41598-017-03775-w Link to publication
Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation., 2017, Neuropeptides 64: 19-25. Hay EA, Knowles C, Kolb A, MacKenzie A. DOI: 10.1016/j.npep.2016.11.010 Link to publication
Determining Epigenetic targets; a beginner’s guide to identifying genome functionality through database analysis, 2017, In Methods in Molecular Biology (Population Epigenetics) 1589: 29-45. Hay EA, Cowie P, MacKenzie A. Link to publication
An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome, 2017, Neuropeptides 64: 101-107. Hay EA, Khalaf AR, Marini P, Brown A, Heath K, Sheppard D, MacKenzie A. DOI: 10.1016/j.npep.2016.11.003. Link to publication
Late stage iodination of biologically active agents using a one-pot process from aryl amines, 2017, Chemical Communications 7: 86: 54881-54891. Sloan N, Luthra SK, McRobbie G, Pimlott SL, Sutherland A. DOI: 10.1039/C7RA11860K Link to publication
A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-Imaging Agents, 2017, Chemical Communications 53: 80:11008-11011. Sloan N, Luthra SK, McRobbie G, Pimlott SL, Sutherland A. DOI: 10.1039/c7cc06211g Link to publication
Current developments in 3D bioprinting for tissue engineering, 2017, Current Opinion in Biomedical Engineering 2: 76-82. Cornelissen D-J. Faulkner-Jones A, Shu W. DOI: 10.1016/j.cobme.2017.05.004 Link to publication
High yield extraction of E. coli RNA from human whole blood, 2017, Journal of Medical Microbiology 66: 301-311. Brennecke J, Kraut S, Zwadlo K, Gandi SK, Pritchard D, Templeton K, Bachmann T. DOI: 10.1099/jmm.0.000439. Link to publication
Novel IgG-degrading enzymes of the IgdE protease family link substrate specificity to host tropism of Streptococcus species, 2017, PLoS ONE 12(1). Spoerry C, Hessle P, Lewis MJ, Paton L, Woof JM, von Pawel-Rammingen U DOI: 10.1371/journal.pone.0164809 Link to publication
Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site, 2016, Tissue Eng Part A, 22 (3-4), p 375-85. Buitinga M, Janeczek Portalska K, Cornelissen DJ, Plass J, Hanegraaf M, Carlotti F, de Koning E, Engelse M, van Blitterswijk C, Karperien M, van Apeldoorn A, de Boer J DOI: 10.1089/ten.tea.2015.0317 Link to publication
The multifaceted role of astrocytes in regulating myelination, 2016, Exp Neurol 283: Pt B: 541-9. Kıray H, Lindsay SL, Hosseinzadeh S, Barnett SC DOI: 10.1016/j.expneurol.2016.03.009 Link to publication
Recent Advances in Transition-Metal-Catalyzed Iodination of Arenes, 2016, Synthesis 48: 18: 2969-2980. Sloan N, Sutherland A. DOI: 10.1055/s-0035-1562439 Link to publication
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